ExecStart=/usr/bin/duplicati-server $DAEMON_OPTS
Duplicati.Server.exe describes your choices in typical manual style, as a list of options, but could use improvement (IMO) on helping pick a set of options for a particular purpose. I guess you get to select.
For typical use accessing Duplicati via localhost (127.0.0.1), I’m not sure if any above are essential.
Mine (which I don’t think I’ve been customizing) looks like below:
# Additional options that are passed to the Daemon.
DAEMON_OPTS=""
Yes, this could be improved. Please see the post above yours on how to register a request for change.