Restoring files if your Duplicati installation is lost seems worth testing somehow to verify it keeps working. Speed of recreate of local database can also be an issue for big backups. Larger blocksize helps speeds.
WinPE and duplicati as Disaster recovery solution and Database backup question discuss BMR issues, including reasons why you might do better with an image-based backup that can do things like partitions, however this may get into specialized software unless you simply want to backup the raw device blocks. There’s also a question of whether you get a backup window or if backups must be done on a live server.