Entire configuration backup

I would suggest to make a copy of the %appdata%\Duplicati folder. If you run Duplicati in portable mode using the --portable-mode option, you have to copy the data folder, located under the Duplicati program folder.
In this folder everything is stored that is needed by Duplicati (Backup jobs, global settings, program settings, local databases, etc.).
Restoring this folder to a computer with a clean installation should revert Duplicati completely to the state it was when creating the copy of these files.
Exporting all backup jobs to JSON files is a good idea, because all settings of a backup job can be retrieved from the JSON file, which is a lot easier then pulling these settings from the SQLITE file.

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