trezcan, in regards to disaster recovery / hardware failure you might want to check out this Topic:
For changing destination locations, yes - it’s pretty much as simple as copying/moving the destination data from one place to another and upating the backup job (or creating a new one) to point to the appropriate path at the new destination.
If you’re workin with USB drives in a Windows environment you might want to check out this page which includes information about the --alternate-destination-marker and --alternate-target-paths parameters which help to deal with Windows sometimes assigning different drive letters the a drive each time you connect it.
For example, you back up to USB at drive letter F then unplug the drive and put it away for safe keeping. For your next backup you already have a thumb drive plugged in and IT got assigned drive letter F so now when you plug in your USB backup drive it gets assigned drive G.
Let us know if these don’t help answer your question! 