Duplicati can’t do direct file copies for backup. Duplicati.CommandLine.BackendTool.exe can put files to Google Drive, but has no drag-and-drop and is kind of a specialty tool. You probably want something else.
Create incremental backups without .zip or any compression is my comment where I point at Fact Sheet for Duplicati and comment on how direct copying is totally contrary to the majority of its design objectives. As someone who doesn’t set priorities, I’m just guessing, but you can see what you think of my opinion…
To be pedantic, I assume you’re really seeking to avoid zip. Some file types don’t compress, but do zip…