Hello @Micah_Silverman and welcome to the forum!
Would it be a good idea of Duplicati would also put the local database (encrypted) on the remote location? came in slightly earlier and is getting the discussion, although not quite a step-by-step. The only things that seem different are the timing (right after the main one) and contents (see Database screen for DB’s path).
Configuration backup wasn’t discussed there, and is a little harder because it’s not just one file per backup. Duplicati-server.sqlite has all the configurations (with passwords), so make sure your backup is encrypted. One still needs some information kept separately, otherwise one won’t be able to decrypt configuration info. Still, having the details easily recoverable is good. One can also export individual configurations for backup.
Entire configuration backup
Backing up the configuration
are earlier discussions done as Support topics. There are likely more, but a Feature request is also helpful.