A backup with zip64 is still failing with "Attempted to write a stream that is larger than 4GiB without setting the zip64 option"

That is an unfortunate error in 2.1.0.5:

The solution is to not set the zip64 option, which will the use the built-in Zip library that supports zip64. Canary builds mark the zip64 flag as deprecated, and always toggle Zip64 for SharpCompress.