For me - 95% of that stuff wouldn’t help in the event of a catastrophic crash, anyway. I’d be reinstalling my programs and in most cases, just manually updating the settings again. I cherrypick the ones where I know exactly which backups would be helpful (plex DB, firefox bookmark saves, notpead++ temp files, etc), and leave the rest basically alone. The real stuff I’m worried about backing up is my big binaries - digital camera photos, scans, dvd and blu-ray rips, and my extensive music collection. And of course most of that stuff is 99% static.
In your case I’d think that having Duplicati store only the last handful of versions might be sufficient. And you’d probably get a good amount of optimization by at least cherrypicking certain temp / cache folders to blacklist from your backups, since those will be data dense and almost completely useless when it comes time to restore from any sort of crash.