No problem.
Given all the problems I had with VSS I eventually ended up exporting my jobs to file, and importing them into the new Duplicati profile that tied to the service account. And when I checked the settings after import I noticed the Home issue.
I suppose export/import is an alternative to moving the databases, but the downside is that you have to run a Repair Database, which on some of my backup targets took more than 24 hours.
Anyway I’d recommend doing an export before trying to move the database so as to have the config(s) saved.