There are definitely tradeoffs, and decompression speed also factors in, and hasn’t been examined…
FWIW which isn’t much given I was mainly testing your compatibility worry, not compression metrics:
102 Original default block in KB. Each compression method used different file
102 None
45 Deflate
43 BZip2
45 LZMA
39 PPMd
Modern Lossless Compression Techniques: Review, Comparison and Analysis
gets into this quite deeply, but can’t account for your particular data, or specific code that Duplicati uses.