I don’t have experience in enterprise scenario (I use duplicati for personal\home use only). Anyway: first to upload data duplicati stores files in a temporary directory. It means:
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For the first backup the whole data will be rewrite to disk.
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For the second and next backups only the difference will be rewrite to disk.
Of course this situation stress the disk. This problem was dealed in other topics. The solution could be a ramdisk? see this topic: Attention SSD users: if your temp directory isn't ram-backed, Duplicati will prematurely wear your SSD