Yes, I have a second backup set configured whose job is to back up ONLY the database from the first backup set. I use the --run-script-after option on the first backup job and point to a batch file. The batch file checks to make sure the previous backup was successful, and if so it triggers the second backup job.
I use this approach on 2 of the 10 computers I back up, the ones with the largest data sets (over 500GB).