I wouldn’t have thought a monthly or even the twice-yearly Windows update would remove the service, but the twice-yearly one can clobber Duplicati configuration and database files if they are kept in the SYSTEM profile.
Migrating from User to Service install on Windows is one place which discusses this, and what to do about it… Although it calls itself a migration guide, info is also useful on first install. Or are you migrating from tray icon?
I know that there are other issues, but I thought I’d start where I could. Some others may need log information.
One other thing I could mention is that Linux distro versions of Mono seem to be a chronic problem, but there aren’t enough specifics here yet to advise an upgrade, unless you want to try it because it often works better.
Do you have anything else going to the Minio remotely, or between houses using any other communications?