I just found this bug today, but basically the TrayIcon keeps a connection to the webserver, and this connection overrides the running backup’s settings
I even marked it as a TODO, but then completely forgot about it:
This means that the --accept-any-ssl-certificate is reset every time the tray-icon requests the status from the webserver …
I think the errors you see on Minio are caused by Duplicati dropping the connection when it sees the invalid certificate.