2.0.4.5 - The process cannot access the file because it is being used by another process

If the stack trace details look similar to original post, there’s an update you might try:

One technical writeup theorizing about what’s going on is:

Database is locked when performing auto-cleanup #4631

If above map helps any, have at it. Duplicati is very much in need of people willing to help in any area, whether it’s helping on forum, test, documentation, or (all-important to forward progress) development.