As others have said, it will definitely work. I did exactly the same thing to seed the backups of my parents’ computers. They back up via WebDAV to a Synology NAS I have at my house.
Note that if you are using the beta version of duplicati, there is a bug that was giving me problems with secure WebDAV. There is a workaround though:
https://forum.duplicati.com/t/ssl-errors-with-webdav-target-even-with-accept-all-cert-option/904